We defined a case as onset from January 1 to October 31, 2007, of bilateral flaccid paraparesis or paraplegia or retention and incontinence of stool or urine, in a patient receiving intrathecal drugs.

Long-Term Incidence and Predictors of Significant Hearing Loss Requiring Hearing Assistive Devices Among Childhood Cancer Survivors: A Population-Based Study Postinduction CNS prophylaxis with ITT did ...

Aug. 2, 2002 -- Prophylactic intrathecal methotrexate significantly reduced recurrence and improved survival for patients in complete remission from aggressive non-Hodgkin's lymphoma (NHL), according ...

We describe the clinical spectrum of IT MTX-related SLS, reported in detail in 31 patients treated as part of the UKALL 2003 trial. Concomitant administration of IV cyclophosphamide and cytosine ...

While cranial radiation therapy (CRT) remains a major risk factor — with high doses of radiation showing a hazard ratio of ...

NEW ORLEANS — A study with the worthwhile goal of attempting to further improve outcomes and reduce toxicity of treatment for children and young adults with acute lymphoblastic leukemia (ALL) or ...

Between 1993 and 1999, 1395 children with ALL (778 boys, 617 girls) were enrolled in the FRALLE 93 study. Informed consent was obtained from all patients’ parents in accordance with national ethic ...

Accord Healthcare, a London-based drugmaker, resumed manufacturing of two methotrexate solutions, according to a Nov. 7 update from the FDA. By March, the American Society of Health-System Pharmacists ...

Methotrexate injection, a treatment for certain autoimmune diseases and cancers, can lead to various side effects. These range from common, mild reactions such as headache and nausea to serious, ...