As part of its wave of airstrikes against Iran this weekend, U.S. Central Command confirmed that it had launched its new low-cost kamikaze drones, the first time the weapons have been used in combat.

Iran unleashed hundreds of drone strikes this weekend on Gulf Arab states, damaging U.S. bases and critical infrastructure and presenting a serious challenge to the Middle East’s air-defense system.

The latest attacks prompted retaliatory strikes from Iran that targeted Israel and U.S. interests throughout the region, including U.S. facilities in Qatar, Kuwait, Bahrain and the United Arab Emirate...